Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

SS Thakur; K Swiderski; JG Ryall; GS Lynch

Journal article

Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

SS Thakur, K Swiderski, JG Ryall, GS Lynch

Philosophical Transactions of the Royal Society B Biological Sciences | ROYAL SOC | Published : 2018

DOI: 10.1098/rstb.2016.0528

Abstract

Duchennemuscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by different genetic mutations leading to aberrant expression or complete absence of cytoskeletal proteins. Dystrophic muscles are prone to injury, and regenerate poorly after damage. Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe musclewasting,weakness and premature death. Many other conditions are similarly characterized by muscle wasting, including sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease. Muscle trauma and loss of mass and physical capacity can significantly..

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University of Melbourne Researchers

Kristy Swiderski Author

Gordon Lynch Author

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Grants

Awarded by Muscular Dystrophy Association

Funding Acknowledgements

This study was supported by research grants from the National Health and Medical Research Council of Australia (APP1009114; APP1065456; APP1103571), Australian Research Council (DP150100206), the Muscular Dystrophy Association, USA (MDA255153), CASS Foundation (SM/12/4269) and Dutch Parent Project (DPPNL, muscular dystrophy). S.S.T. is supported by a Australian Government Research Training Program Scholarship, a June Opie Fellowship and a Lionel Murphy Endowment Scholarship.